Temporary Menopause Injections

Temporary Menopause Injections (GnRH Analogues) – Comprehensive Guide

What Are Temporary Menopause Injections?

Temporary menopause injections are medications known as GnRH analogues that temporarily create a menopause-like state in the body. They are primarily used in the treatment of endometriosis and uterine fibroids.

How Do They Work?

These medications suppress the pituitary gland, reducing estrogen production. As estrogen levels decrease, endometriotic lesions shrink and pain is reduced.

Which Medications Are Used?

Leuprolide acetate, goserelin, and triptorelin are the most commonly used GnRH analogues. They are typically administered as monthly or 3-monthly injections.

In Which Patients Are They Used?

They are used in patients with severe endometriosis pain, to shrink lesions before surgery, or to reduce recurrence after surgery.

Advantages

They provide strong hormonal suppression, significantly reduce pain, and control disease activity.

Side Effects

Hot flashes, sweating, vaginal dryness, decreased bone density, and mood changes may occur. These effects are due to low estrogen.

What is Add-back Therapy?

Low-dose estrogen and/or progesterone can be added to reduce side effects. This approach is called add-back therapy.

How Long Are They Used?

They are generally used for 3-6 months. Caution should be exercised regarding bone health with longer use.

Effect on Fertility

They temporarily suppress ovulation, but fertility usually returns after treatment is discontinued.

When Are They Not Preferred?

Caution should be exercised due to the risk of bone density loss with long-term use. They are not used during pregnancy.

Conclusion

GnRH analogues are an effective option in the treatment of endometriosis but require careful patient selection and follow-up due to their side effects.