Osteoporosis Current Treatment

Current Treatments in Osteoporosis – A Comprehensive Guide

Current Approach in Osteoporosis

Today, osteoporosis treatment is based not only on stopping bone loss but also on increasing new bone formation. Treatment selection is individualized according to the patient's fracture risk, age, and clinical condition.

Antiresorptive Therapies

Bisphosphonates (alendronate, zoledronic acid) and denosumab reduce bone breakdown. These treatments, used for many years, are still considered first-line.

Osteoanabolic Therapies

Teriparatide and abaloparatide are drugs that increase bone formation. They are particularly preferred in advanced osteoporosis and high fracture risk.

Next-Generation Treatment: Romosozumab

Romosozumab is a sclerostin inhibitor that both increases bone formation and reduces bone breakdown. It is one of the most powerful options among current treatments.

Sequential Treatment Approach

In the modern approach, drugs that increase bone formation are used first, followed by treatments that reduce bone breakdown. This method provides the highest efficacy.

Biological Therapies

Monoclonal antibodies such as denosumab and romosozumab are targeted therapies and are particularly preferred in high-risk patients.

How Is Treatment Selected?

The most suitable treatment is selected by evaluating the patient's age, menopausal status, fracture history, and bone mineral density together.

Endometriosis and Osteoporosis

Treatments such as GnRH analogs can reduce bone density. Therefore, bone health should be closely monitored in these patients.

Preventive Approach

Calcium, Vitamin D, exercise, and lifestyle changes form the basis of treatment.

Conclusion

Osteoporosis treatment is rapidly evolving. With current treatments, fracture risk can be significantly reduced, and quality of life can be improved.