Endometriosis Recurrence

14.05.2026 Prof. Dr. Cihan Kaya

Risk of Recurrence (Relapse) in Endometriosis – A Comprehensive Guide

What is Recurrence in Endometriosis?

Endometriosis is a chronic disease with a tendency to recur. The re-emergence of symptoms or lesions after treatment is defined as recurrence.

How Often Does Recurrence Occur?

The recurrence rate within 5 years after surgery is reported to be between 20-50%. This rate varies depending on the stage of the disease and the treatment applied.

Why Does Recurrence Happen?

Remaining microscopic lesions, hormonal effects, genetic predisposition, and inadequate surgical excision are the main causes of recurrence.

Risk Factors

Young age, advanced stage disease, bilateral endometrioma, inadequate surgery, and not receiving hormonal treatment increase the risk of recurrence.

Surgery-Related Recurrence

Incomplete excision or overlooking deep infiltrative lesions increases the risk of recurrence. An experienced surgeon is an important factor.

Hormonal Factors

Since it is an estrogen-dependent disease, lesions may regrow if hormonal suppression is not performed.

Return of Symptoms

The re-onset of pain, menstrual cramps, and infertility complaints can be the first signs of recurrence.

How to Prevent Recurrence?

Post-surgical hormonal treatment (progesterone, COCs, LNG-IUS), regular follow-up, and appropriate lifestyle changes can reduce recurrence.

Endometriosis and Pregnancy

Pregnancy and breastfeeding periods can temporarily suppress the disease, but they are not a permanent solution.

Follow-up Recommendations

It is important for patients to be monitored with regular check-ups and evaluated for early symptoms.

Conclusion

Endometriosis is a disease that can recur. However, with correct surgery, appropriate medical treatment, and regular follow-up, this risk can be significantly reduced.

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