Endometriosis Postoperative Suppression

14.05.2026 Prof. Dr. Cihan Kaya

Post-Surgical Suppression Therapy in Endometriosis – Comprehensive Guide

What is Post-Surgical Suppression Therapy?

Hormonal treatments applied after endometriosis surgery are called suppression therapy. The aim is to prevent the growth of remaining microscopic foci and reduce the risk of recurrence.

Why is it Necessary?

Endometriosis is a chronic disease with a tendency to recur. If hormonal suppression is not performed after surgery, the risk of recurrence can significantly increase.

In Which Patients is it Recommended?

It is especially recommended for patients with pain symptoms, advanced-stage disease, young age, and no fertility plans.

Treatment Options Used

Progestins (dienogest), combined oral contraceptives, hormonal IUDs (LNG-IUS), and GnRH analogues are the most commonly used options.

Progestin Treatments

It is a first-line treatment. It is suitable for long-term use, and its side effect profile is generally tolerable.

Combined Oral Contraceptives

Continuous use can suppress menstruation, reducing pain and the risk of recurrence.

Hormonal IUD (LNG-IUS)

With its local progestin effect, it is particularly effective in patients with pelvic pain and concomitant adenomyosis.

GnRH Analogues

They provide stronger suppression but are generally used for short periods due to side effects and are preferred in selected patients.

Duration of Treatment

Suppression therapy is usually planned for the long term. The duration of treatment varies according to the patient's age, symptoms, and pregnancy plans.

Patients with Fertility Plans

In patients planning pregnancy, timely pregnancy or IVF planning should be considered instead of long-term suppression.

Efficacy in Preventing Recurrence

Regular hormonal treatment significantly reduces the risk of recurrence after surgery and provides symptom control.

Conclusion

Post-surgical suppression therapy is a critical part of endometriosis management. The best results are achieved with personalized planning.

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