Ivf Steroid

14.05.2026 Prof. Dr. Cihan Kaya

Steroid Use in IVF Treatment – A Comprehensive Guide

What is a Steroid?

Steroids (e.g., prednisolone) are medications that suppress the immune system. They can be used as supportive treatment in some selected patients during IVF.

What is the Purpose of Steroid Use in IVF?

• To regulate the immune system
• To reduce a possible immune response against the embryo
• To support implantation

Who Uses It?

• Recurrent IVF failure
• Recurrent pregnancy loss
• Suspected immunological factors
• Certain selected patient groups

Is Routine Use Necessary?

No. Routine steroid use is not recommended for all patients. It may only be beneficial in specific patient groups.

When is it Started?

It is generally started before embryo transfer or on the day of transfer. The duration of use varies depending on the patient.

Method of Use

It is used in the form of low-dose oral tablets. The dose and duration are determined by the doctor.

Side Effects

• Increased appetite
• Edema
• Mood changes
• Sleep problems

Risks of Long-Term Use

• Increased blood sugar
• Immune suppression
• Bone loss (with long-term use)

Who Should Use It Cautiously?

• Diabetic patients
• Those with a high risk of infection
• Those using steroids for a long time

Clinical Fact

Steroids may be beneficial in some selected patients, but it is not certain that routine use increases pregnancy rates.

Conclusion

Steroid treatment in the IVF process should be personalized. Unnecessary use does not provide benefit and increases the risk of side effects.

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