He4 Blog

What is HE4? – Comprehensive Guide

What is HE4?

HE4 (Human Epididymis Protein 4) is a tumor marker primarily used in the evaluation of ovarian cancer. Its diagnostic value increases when used in conjunction with CA125.

Why is HE4 Important?

HE4 is considered a more specific marker, especially in ovarian cancer. Compared to CA125, it shows less elevation in some benign conditions, thus providing an advantage in differential diagnosis.

In Which Conditions Does HE4 Elevate?

HE4 most commonly elevates in ovarian cancer. Additionally, an increase may be observed in kidney dysfunction and some other malignant conditions.

Difference Between HE4 and CA125

While CA125 can elevate in many benign conditions, HE4 is considered more specific. Therefore, using both tests together allows for a more accurate evaluation.

What is the ROMA Score?

ROMA (Risk of Ovarian Malignancy Algorithm) is an algorithm that calculates the risk of ovarian cancer by evaluating HE4 and CA125 values along with menopausal status.

What is the Normal Value of HE4?

While the reference range for HE4 varies by laboratory, different thresholds are generally used for pre-menopausal and post-menopausal women.

What Does Elevated HE4 Mean?

Elevated HE4 alone does not mean cancer, but it should be evaluated in conjunction with other findings.

Diagnostic Process

HE4 is evaluated in conjunction with ultrasound and other imaging methods. Further investigations are planned if necessary.

When Should You Consult a Doctor?

In the presence of symptoms such as a suspicious mass, increased marker values, or pelvic pain, expert evaluation is absolutely necessary.

Conclusion

HE4 is an important biomarker in the evaluation of ovarian cancer. However, it is not sufficient on its own and should be interpreted in conjunction with other clinical findings.