Adenomyosis Hormone

Hormone Therapy in Adenomyosis – A Comprehensive Guide

What is Hormone Therapy in Adenomyosis?

Hormone therapy in adenomyosis is a medical approach aimed at reducing symptoms by suppressing the estrogen-dependent nature of the disease. It is particularly used to control pain and heavy menstrual bleeding.

How Does It Work?

Hormonal treatments reduce the effect of estrogen or increase the effect of progesterone. This suppresses the activity of adenomyotic tissue within the uterus, and symptoms decrease.

Progesterone Treatments

Dienogest, medroxyprogesterone, and other progestins are the most commonly used agents. They are suitable for long-term use and reduce pain and bleeding.

Hormonal IUD (LNG-IUS)

The levonorgestrel-releasing IUD is highly effective, particularly for heavy menstrual bleeding and pain, due to its local progesterone effect.

Combined Oral Contraceptives

Pills containing estrogen and progesterone regulate the menstrual cycle and can reduce symptoms with continuous use.

GnRH Analogues

They create a temporary menopause effect, lowering estrogen levels. They provide a strong effect but are generally used for short periods.

Aromatase Inhibitors

These drugs, which reduce estrogen production, can be used in resistant cases but are generally preferred as an adjunct to other treatments.

In Which Patients Is It Preferred?

It is preferred as a first-line treatment in patients who do not desire surgery, do not plan pregnancy, or require symptom control.

Side Effects

Breakthrough bleeding, weight changes, mood swings, and menopause-like complaints may be observed with GnRH use.

Effect on Fertility

Pregnancy does not occur as long as hormonal treatments are used. Therefore, the treatment strategy should be carefully determined in patients planning pregnancy.

Duration of Treatment

Long-term use is possible. The duration of treatment is determined according to the patient's age, symptoms, and expectations.

Conclusion

Hormone therapy in adenomyosis is an effective and safe option for symptom control. Quality of life can be significantly improved with personalized planning.